Vitaminen b17


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Einleitung was ist Vitamin, b17


19 For example, a 1982 trial by the mayo clinic of 175 patients found that tumor size had increased in all but one patient. 27 The authors reported that "the hazards of amygdalin therapy were evidenced in several patients by symptoms of cyanide toxicity or by blood cyanide levels approaching the lethal range." The study concluded "Patients exposed to this agent should be instructed about the danger of cyanide. Amygdalin (Laetrile) is a toxic drug that is not effective as a cancer treatment". Additionally, "No controlled clinical trials (trials that compare groups of patients who receive the new treatment to groups who do not) of laetrile have been reported." 28 The side effects of laetrile treatment are the symptoms of cyanide poisoning. These symptoms include: nausea and vomiting, headache, dizziness, cherry red skin color, liver damage, abnormally low blood pressure, droopy upper eyelid, trouble walking due to damaged nerves, fever, mental confusion, coma, and death. The european food Safety Agency 's Panel on Contaminants in the food Chain has studied the potential toxicity of the amygdalin in apricot kernels. The panel reported, "If consumers follow the recommendations of websites that promote consumption of apricot kernels, their exposure to cyanide will greatly exceed" the dose expected to be toxic. The panel also reported that acute cyanide toxicity had occurred in adults who had consumed 20 or more kernels and that in children "five or more kernels appear to be toxic".

States legalized the use of amygdalin within those states. 23 Subsequent results In spiermassa a 1977 controlled, blinded trial, laetrile showed no more activity than placebo. 24 Subsequently, laetrile was tested on 14 tumor systems without evidence of effectiveness. The memorial SloanKettering Cancer Center (mskcc) concluded that "laetrile showed no beneficial effects." 24 Mistakes in an earlier mskcc press release were highlighted by a group of laetrile proponents led by ralph Moss, former public affairs official of mskcc who had been fired following his. 25 These mistakes were considered scientifically inconsequential, but Nicholas Wade in Science stated that "even the appearance of a departure from strict objectivity is unfortunate." 24 The results from these studies were published all together. 26 A 2015 systematic review from the cochrane collaboration found: The claims that laetrile or amygdalin have beneficial effects racefiets for cancer patients are not currently supported by sound clinical data. There is a considerable risk of serious adverse effects from cyanide poisoning after laetrile or amygdalin, especially after oral ingestion.

The riskbenefit balance of laetrile or amygdalin as a treatment for cancer is therefore unambiguously negative. 3 The authors also recommended, on ethical and scientific grounds, that no further clinical research into laetrile or amygdalin be conducted. 3 given the lack of evidence, laetrile has not been approved by the. Food and Drug Administration or the european Commission. National Institutes of health evaluated the evidence separately and concluded that clinical trials of amygdalin showed little or no effect against cancer.

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This was considered untenable. Finally, the third asserted that laetrile is the discovered vitamin B-17, and further suggests that cancer is a result of "B-17 deficiency". It postulated that regular dietary administration of this form of laetrile would, therefore, actually prevent all incidence of cancer. The term "vitamin B-17" is not recognized by committee on Nomenclature of the American Institute of Nutrition Vitamins. 15 There is no credible evidence supporting this conjecture. Krebs branded laetrile as a vitamin in order to have it classified as a nutritional supplement rather than as a pharmaceutical.

2 History of laetrile early usage Amygdalin was first isolated in 1830 from bitter almond seeds ( Prunus dulcis ) by pierre-jean Robiquet and Antoine boutron-Charlard. 16 liebig and Wöhler found three hydrolysis products of amygdalin: sugar, benzaldehyde, and prussic acid (hydrogen cyanide). 17 Later research showed that sulfuric acid hydrolyzes it into d-glucose, benzaldehyde, and prussic acid; while hydrochloric acid gives mandelic acid, d-glucose, and ammonia. 18 In 1845 amygdalin was used as a cancer treatment in Russia, and in the 1920s in the United States, but it was considered too poisonous. S, a purportedly non-toxic, synthetic form was patented for use as a meat preservative, 20 and later marketed as laetrile for cancer treatment. Food and Drug Administration prohibited the interstate shipment of amygdalin and laetrile in 1977. 21 22 Thereafter,.

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The usual preferred commercial source is makkelijk from apricot kernels ( Prunus armeniaca ). The name is derived from the separate words "laevarotatory" and "mandelonitrile". Laevarotatory describes the stereochemistry of the molecule, while mandelonitrile afslanken refers to its chemical identity 11 A 500 mg laetrile tablet may contain between 551 mg of hydrogen cyanide per gram. 12 like amygdalin, laetrile is hydrolyzed in the duodenum (alkaline) and in the intestine (enzymatically) to d- glucuronic acid and l- mandelonitrile ; the latter hydrolyzes to benzaldehyde and hydrogen cyanide, that in sufficient quantities causes cyanide poisoning. 13 Claims for laetrile were based on three different hypotheses: 14 The first hypothesis proposed that cancerous cells contained copious beta-glucosidases, which release hcn from laetrile via hydrolysis. Normal cells were reportedly unaffected, because they contained low concentrations of beta-glucosidases and high concentrations of rhodanese, which converts hcn to the less toxic thiocyanate. Later, however, it was shown that both cancerous and normal cells contain only trace amounts of beta-glucosidases and similar amounts of rhodanese. 14 The second proposed that, after ingestion, amygdalin was hydrolyzed to mandelonitrile, transported intact to the liver and converted to a beta-glucuronide complex, which was then carried to the cancerous cells, hydrolyzed by beta-glucuronidases to release mandelonitrile and then hcn.

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8 Natural amygdalin has the ( R )-configuration at the chiral phenyl center. Under mild basic conditions, this stereogenic center isomerizes; the ( S )-epimer is aambei called neoamygdalin. Although the synthesized version of amygdalin is the ( R )-epimer, the stereogenic center attached to the nitrile and phenyl groups easily epimerizes if the manufacturer does not store the compound correctly. 9 Amygdalin is hydrolyzed by intestinal β-glucosidase (emulsin) 10 and amygdalase to give gentiobiose and l- mandelonitrile. Gentiobiose is further hydrolyzed to give glucose, whereas mandelonitrile (the cyanohydrin of benzaldehyde ) decomposes to give benzaldehyde and hydrogen cyanide. Hydrogen cyanide in sufficient quantities ( allowable daily intake :.6 mg) citation needed causes cyanide poisoning (fatal oral dose:.61.5 mg/kg) citation needed. Apricot pits contain 892,170 mg/kg hydrogen cyanide (wet weight). Citation needed laetrile laetrile (patented 1961) is a simpler semisynthetic version of amygdalin. Laetrile is synthesized from amygdalin by hydrolysis.

2, contents Chemistry Amygdalin is a cyanogenic glycoside derived from the aromatic amino acid phenylalanine. Amygdalin and prunasin are common among plants of the family rosaceae, particularly the genus Prunus, poaceae (grasses fabaceae (legumes and in other food plants, including flaxseed and manioc. Within lever these plants, amygdalin and the enzymes necessary to hydrolyze them are stored in separate locations so that they will mix in response to tissue damage. This provides a natural defense system. 6 Amygdalin is contained in stone fruit kernels, such as apricot (1.4 peach (0.68 bitter almond (5 citation needed and plum (0.041.7 and also in the seeds of the apple (0.3). 7 The stones are taken out of the fruit and cracked to obtain the kernels, which are dried in the sun or in ovens. The kernels are boiled in ethanol ; on evaporation of the solution and the addition of diethyl ether, amygdalin is precipitated as minute white crystals.

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Amygdalin (from, ancient Greek : μυγδαλή amygdálē "almond is a naturally occurring chemical compound, famous for falsely being promoted as a cancer cure. It is found in many plants, but most notably in the seeds (kernels) of apricot, bitter almonds, apple, peach, and plum. Amygdalin is classified as a cyanogenic glycoside because each amygdalin molecule includes a nitrile group, which can be released as the toxic cyanide anion by the action paleo of a beta-glucosidase: eating amygdalin will cause it to release cyanide in the human body, and may lead. 1, neither amygdalin nor laetrile is a vitamin. Since the early 1950s, both amygdalin and a modified form named laetrile have been promoted as alternative cancer treatments, often using the misnomer vitamin B17. 2, but studies have found them to be clinically ineffective in the treatment of cancer, as well as potentially toxic or lethal when taken by mouth, due to cyanide poisoning. 3, the promotion of laetrile to treat cancer has been described in the medical literature as a canonical example of quackery, 4 5 and as "the slickest, most sophisticated, and certainly the most remunerative cancer quack promotion in medical history".

Vitaminen b17
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